England April 2015 to June 2024

Published 17 October 2024

Key findings

In England in 2023/24:

13 million HRT items were prescribed to an estimated 2.6 million identified patients.

The number of identified patients prescribed HRT was higher in less deprived areas.

The most common age group to be prescribed HRT was patients aged 50 to 54.

In England in 2023/24 there were 13 million Hormone Replacement Therapy (HRT) items prescribed, a 22% increase since 2022/23. The estimated number of identified patients increased by 12%, from 2.3 million in 2022/23 to 2.6 million in 2023/24.

Utrogestan 100mg tablets was the British National Formulary (BNF) presentation with both the highest number of items prescribed and identified patients in 2023/24. Utrogestan 100mg tablets increased by 42% in 2023/24 to 1.3 million items, up from 940,000 in 2022/23.

The least deprived areas in England had more than twice as many identified patients receiving HRT prescribing compared to the most deprived areas.

The proportion of HRT items for which an HRT Prescription Prepayment Certificate (HRT PPC) was used was 14.5% in 2023/24. This proportion has increased to 21% in June 2024.


1. Things you should know

1.1. Introduction

This publication aims to describe the prescribing of HRT medications in England. These medications are subsequently dispensed in the community in England, Scotland, Wales, Isle of Man or the Channel Islands.

Dispensing can be done by a pharmacy, appliance contractor, dispensing doctor, or have been personally administered by a GP practice. This publication does not include data on medicines used in secondary care, prisons, or issued by a private prescriber. The statistics do not include prescriptions that were issued but not presented for dispensing or where there has been an unmet demand for treatment.

1.2. Scope

These statistics detail:

  • the total number of prescription items issued for drugs that appear on the HRT Prescription Prepayment Certificate (HRT PPC) drug list
  • the number of identified patients that have received prescribing for these drugs
  • demographic breakdowns of prescribing by age group
  • demographic breakdowns by a measure of deprivation.

The costs associated with the provision of these medicines are not discussed in this summary. However, they are available within the supporting summary tables that accompany this release.

There is no single definition of HRT medications. Many other products may be used in the treatment of the menopause that are not included in these statistics. This publication uses ‘HRT’ as a catch-all term to refer to all drugs that appear on the HRT PPC drug list. Some medications included on the list may not meet other definitions of HRT when prescribed alone instead of in combination with another medication.

The release is limited to all drugs that are covered by the HRT PPC, which is intended to cover all drugs licensed to treat menopause in the UK. You can find the most up to date list of drugs included in the HRT PPC on the NHSBSA website.

These statistics use the therapeutic classifications defined in the BNF, using the classification system prior to BNF edition 70. Each January the NHSBSA updates the classification of drugs within the BNF hierarchy, and this may involve some drugs changing classification between years of data.

Medicines are classified by their primary therapeutic indication. However, sometimes a medicine may be prescribed for a reason other than the primary therapeutic indication. For example, the treatment of gender dysphoria. The clinical indication of a prescription is not captured by NHSBSA during processing, and therefore we cannot determine the reason that a prescription was issued.

Data in this publication does not distinguish between patients of different genders and has not been limited to agebands where menopause is common.

The scope of this publication means that numbers in the statistical summary narrative and supporting summary tables may not match totals published in other reports that use different methodology.

1.3. Background

Hormone Replacement Therapy (HRT) is a treatment to relieve symptoms of the menopause. It replaces hormones that are at a lower level during the perimenopause, menopause, and postmenopause.

Menopause is when periods stop due to lower hormone levels. It usually affects women between the ages of 45 and 55, but it can happen earlier. It affects anyone who has periods.

Many women experience some symptoms, such as vaginal dryness, low mood, anxiety, hot flushes and difficulty sleeping. Some of these symptoms can be severe and have a negative impact on everyday life.

1.4. Definitions

Item

A single unit of medication listed separately on a prescription form. In this publication, an example of an item would be Estradiol 2mg tablets x84.

Patient

A unique NHS number captured from a prescription form or electronic prescription service (EPS) message.

NIC

The Net Ingredient Cost (NIC) is the basic price of the medication and the quantity prescribed. It does not include other fees incurred by dispensing contractors, such as controlled drug fees or the single activity fee. The basic price is determined by the Drug Tariff or by the manufacturer, wholesaler, or supplier of the product.

Age

Where patients are identified, their age is calculated on 30 September of the given financial year to assign them to a single age band. For patients where date of birth has not been captured, they have been included in a category of unknown.

1.5. Time periods

This publication presents data from April 2015 to June 2024, the most recent available. Data is available in the supporting summary tables at both a monthly and a financial year level. Financial year 2023/24 covers April 2023 to March 2024. The most recent financial year, 2024/25, shows a year to date (YTD) view of the figures from April 2024 to June 2024.

1.6. Patient identification

When the NHSBSA processes prescriptions, the NHS number of the patient is identified for most, but not all, prescriptions. The proportion of items for which a patient could be identified is shown in Table 1. This means that data relating to patient counts represents most, but not all, patients.

These statistics do not contain any personally identifiable data. More information about how the NHSBSA protects personal information can be found in the statement on confidentiality and access.

Table 1: The proportion of items for which an NHS number was recorded for listed BNF paragraphs

BNF paragraph name 2020/2021 2021/2022 2022/2023 2023/2024 2024/25 YTD June 2024
Female sex hormones and their modulators 99.2% 99.3% 99.2% 99.3% 99.4%
Preparations for vaginal and vulval changes 99.1% 99.1% 99.0% 99.1% 99.2%
Progestogen-only contraceptives 95.5% 95.0% 94.5% 94.8% 95.0%
Anabolic steroids 98.2% 98.1% 97.5% 98.4% 98.6%

Source: Hormone Replacement Therapy summary tables - annual


2. Results and commentary

Number of prescribed items and estimated identified patients by financial year

Chart
Figure 1: The number of items prescribed and identified patients have both increased every year since 2015/16
Table
Table 2: The number of items prescribed and identified patients have both increased every year since 2015/16
Financial year Prescribed items Identified patients
2015/2016 3,129,196 1,028,430
2016/2017 3,508,052 1,135,551
2017/2018 4,007,383 1,248,736
2018/2019 4,497,327 1,344,640
2019/2020 5,297,429 1,455,591
2020/2021 5,420,813 1,384,489
2021/2022 7,440,662 1,813,228
2022/2023 10,933,456 2,344,680
2023/2024 13,285,168 2,634,976
2024/2025
(YTD June 2024)
3,586,907 1,882,770

Source: Hormone Replacement Therapy summary tables - annual

13 million HRT items prescribed in 2023/24.

2.6 million identified patients received an HRT item in 2023/24.

Items and patients have both continued to trend upwards.

In 2023/24 there were 13.3 million HRT drug items prescribed, a 21.5% increase from the 10.9 million items prescribed in 2022/23.

An estimated 2.63 million identified patients were prescribed at least one HRT drug item in 2023/24. This was a 12.4% increase compared to 2.34 million patients in the previous year.

Between April 2024 and June 2024 there were 3.59 million HRT drug items prescribed. This was a 17.8% increase from 3.04 million items in the same time period in the previous year.

Number of prescribed items and estimated identified patients by month

Chart
Figure 2: The number of items and identified patients is generally increasing over time but varies by month
Table
Table 3: The number of items and identified patients is generally increasing over time but varies by month
Year month Prescribed items Identified patients
202207 876,717 659,911
202208 908,441 685,038
202209 914,272 689,601
202210 945,652 711,007
202211 957,416 727,938
202212 941,902 708,446
202301 964,722 733,027
202302 913,168 705,325
202303 1,064,006 795,590
202304 969,410 733,082
202305 1,034,470 783,652
202306 1,040,462 797,465
202307 1,162,877 845,271
202308 1,120,277 830,077
202309 1,111,729 828,674
202310 1,133,254 843,359
202311 1,143,630 850,765
202312 1,116,460 832,740
202401 1,189,229 878,214
202402 1,116,340 835,322
202403 1,147,030 853,565
202404 1,194,875 884,390
202405 1,227,875 904,544
202406 1,164,157 865,561

Source: Hormone Replacement Therapy summary tables - monthly

1.2 million HRT items prescribed in June 2024.

870,000 identified patients received an HRT item in June 2024.

There were 1.16 million HRT drug items prescribed in June 2024. This was a decrease of 5.19% from 1.23 million items in May 2024, and a 11.9% increase from 1.04 million items in June 2023.

An estimated 866,000 identified patients were prescribed at least one HRT drug item in June 2024, a 4.31% decrease from the previous month.

Number of prescribed items and estimated identified patients by financial year and selected drug groups

In 2023/24, almost 99% of all HRT items were from 2 drug groups. These drug groups were BNF paragraph 6.4.1 female sex hormones and their modulators, and BNF paragraph 7.2.1 preparations for vaginal and vulval changes.

The charts in figure 3 show a rolling five-year time series, along with the year to date for 2024/25. The data is limited to items in these BNF paragraphs that are also included in the HRT PPC drug list.

Chart
Figure 3: Items and identified patients in the 2 largest drug groups have increased over time
Table
Table 4: Items and identified patients in the 2 largest drug groups have increased over time
Financial year BNF paragraph Prescribed items Identified patients
2019/2020 060401 3,453,153 822,535
2019/2020 070201 1,715,402 588,980
2020/2021 060401 3,627,282 815,172
2020/2021 070201 1,705,547 558,807
2021/2022 060401 5,259,408 1,153,409
2021/2022 070201 2,053,709 684,739
2022/2023 060401 8,254,779 1,612,621
2022/2023 070201 2,536,024 832,778
2023/2024 060401 10,235,478 1,844,036
2023/2024 070201 2,902,877 941,295
2024/2025
(YTD June 2024)
060401 2,758,019 1,423,044
2024/2025
(YTD June 2024)
070201 794,164 560,332

Source: Hormone Replacement Therapy summary tables - annual

10 million female sex hormones and their modulators items prescribed in 2023/24.

2.9 million preparations for vaginal and vulval changes items prescribed in 2023/24.

In 2023/24 there were 10.2 million female sex hormones and their modulators items prescribed, a 24.0% increase from 8.25 million items in the previous year.

There were an estimated 1.84 million identified patients who were prescribed at least one female sex hormones and their modulators item in 2023/24. This was a 14.4% increase compared to the 1.61 million identified patients in 2022/23.

In 2023/24 there were 2.90 million preparations for vaginal and vulval changes items prescribed. This was a 14.5% increase from 2.54 million items in the previous year.

An estimated 941,000 identified patients were prescribed at least one preparations for vaginal and vulval changes item in 2023/24. This was a 13.0% increase from 833,000 identified patients in 2022/23.

Estimated number of identified patients by financial year for selected BNF chemical substances

Chemical substance

A chemical substance is the name of the main active ingredient in a drug. The chemical substances featured in figure 4 and figure 5 are the top 5 most prescribed chemical substances for HRT prescribing. Although chemical substance is a grouping within the BNF, when a drug is available in different presentations with disparate uses it may be listed in multiple sections or paragraphs. In this case the drug will be assigned multiple chemical substances codes, one for each section it is in.

This is the case for Estradiol, which has a code for female sex hormones and their modulators, and another code for preparations for vaginal and vulval changes. The chemical substance code is included in the figures and commentary to distinguish between the prescribing for each drug group.

Chart
Figure 4: Estradiol (0604011G0) was the HRT chemical substance with the most identified patients in 2023/24
Table
Table 5: Estradiol (0604011G0) was the HRT chemical substance with the most identified patients in 2023/24
Financial year BNF chemical substance Identified patients
2015/2016 Estradiol - 0604011G0 183,678
2015/2016 Estradiol with progestogen - 0604011L0 220,096
2015/2016 Progesterone - 0604012S0 6,581
2015/2016 Estriol - 0702010F0 193,358
2015/2016 Estradiol - 0702010G0 259,704
2016/2017 Estradiol - 0604011G0 207,604
2016/2017 Estradiol with progestogen - 0604011L0 265,083
2016/2017 Progesterone - 0604012S0 9,392
2016/2017 Estriol - 0702010F0 206,672
2016/2017 Estradiol - 0702010G0 287,960
2017/2018 Estradiol - 0604011G0 233,098
2017/2018 Estradiol with progestogen - 0604011L0 334,961
2017/2018 Progesterone - 0604012S0 14,686
2017/2018 Estriol - 0702010F0 216,076
2017/2018 Estradiol - 0702010G0 312,662
2018/2019 Estradiol - 0604011G0 266,046
2018/2019 Estradiol with progestogen - 0604011L0 379,423
2018/2019 Progesterone - 0604012S0 25,760
2018/2019 Estriol - 0702010F0 230,847
2018/2019 Estradiol - 0702010G0 341,707
2019/2020 Estradiol - 0604011G0 345,684
2019/2020 Estradiol with progestogen - 0604011L0 401,869
2019/2020 Progesterone - 0604012S0 79,239
2019/2020 Estriol - 0702010F0 247,725
2019/2020 Estradiol - 0702010G0 369,283
2020/2021 Estradiol - 0604011G0 363,497
2020/2021 Estradiol with progestogen - 0604011L0 367,668
2020/2021 Progesterone - 0604012S0 111,282
2020/2021 Estriol - 0702010F0 235,338
2020/2021 Estradiol - 0702010G0 348,267
2021/2022 Estradiol - 0604011G0 592,795
2021/2022 Estradiol with progestogen - 0604011L0 519,784
2021/2022 Progesterone - 0604012S0 258,148
2021/2022 Estriol - 0702010F0 300,731
2021/2022 Estradiol - 0702010G0 421,514
2022/2023 Estradiol - 0604011G0 954,923
2022/2023 Estradiol with progestogen - 0604011L0 680,010
2022/2023 Progesterone - 0604012S0 505,319
2022/2023 Estriol - 0702010F0 371,130
2022/2023 Estradiol - 0702010G0 513,684
2023/2024 Estradiol - 0604011G0 1,181,842
2023/2024 Estradiol with progestogen - 0604011L0 704,538
2023/2024 Progesterone - 0604012S0 648,493
2023/2024 Estriol - 0702010F0 431,623
2023/2024 Estradiol - 0702010G0 569,506
2024/2025
(YTD June 2024)
Estradiol - 0604011G0 902,886
2024/2025
(YTD June 2024)
Estradiol with progestogen - 0604011L0 446,791
2024/2025
(YTD June 2024)
Progesterone - 0604012S0 471,923
2024/2025
(YTD June 2024)
Estriol - 0702010F0 232,960
2024/2025
(YTD June 2024)
Estradiol - 0702010G0 343,983

Source: Hormone Replacement Therapy summary tables - annual

In 2023/24 Estradiol (0604011G0) remained the chemical substance with the largest number of estimated identified patients.

1.2 million identified patients were prescribed at least one Estradiol (0604011G0) item in 2023/24.

Estradiol (0604011G0) was the chemical substance with the largest increase in estimated identified patients between 2022/23 and 2023/24.

An estimated 1.18 million identified patients were prescribed at least one Estradiol (0604011G0) item in 2023/24. This was an increase of 227,000 patients, or 23.8%, from 955,000 identified patients in 2022/23.

Number of prescribed items by financial year for selected BNF chemical substances

Chart
Figure 5: Estradiol (0604011G0) was the most prescribed HRT chemical substance by items in 2023/24
Table
Table 6: Estradiol (0604011G0) was the most prescribed HRT chemical substance by items in 2023/24
Financial year BNF chemical substance Total items
2015/2016 Estradiol - 0604011G0 712,148
2015/2016 Estradiol - 0702010G0 667,785
2015/2016 Estradiol with progestogen - 0604011L0 638,248
2015/2016 Estriol - 0702010F0 453,408
2015/2016 Progesterone - 0604012S0 21,875
2016/2017 Estradiol - 0604011G0 813,258
2016/2017 Estradiol - 0702010G0 749,144
2016/2017 Estradiol with progestogen - 0604011L0 773,541
2016/2017 Estriol - 0702010F0 492,827
2016/2017 Progesterone - 0604012S0 31,396
2017/2018 Estradiol - 0604011G0 922,880
2017/2018 Estradiol - 0702010G0 829,574
2017/2018 Estradiol with progestogen - 0604011L0 1,013,956
2017/2018 Estriol - 0702010F0 529,980
2017/2018 Progesterone - 0604012S0 47,732
2018/2019 Estradiol - 0604011G0 1,068,454
2018/2019 Estradiol - 0702010G0 930,147
2018/2019 Estradiol with progestogen - 0604011L0 1,190,018
2018/2019 Estriol - 0702010F0 586,081
2018/2019 Progesterone - 0604012S0 82,869
2019/2020 Estradiol - 0604011G0 1,354,548
2019/2020 Estradiol - 0702010G0 1,053,492
2019/2020 Estradiol with progestogen - 0604011L0 1,289,913
2019/2020 Estriol - 0702010F0 661,910
2019/2020 Progesterone - 0604012S0 224,155
2020/2021 Estradiol - 0604011G0 1,517,555
2020/2021 Estradiol - 0702010G0 1,044,356
2020/2021 Estradiol with progestogen - 0604011L0 1,186,569
2020/2021 Estriol - 0702010F0 661,191
2020/2021 Progesterone - 0604012S0 377,687
2021/2022 Estradiol - 0604011G0 2,303,883
2021/2022 Estradiol - 0702010G0 1,229,740
2021/2022 Estradiol with progestogen - 0604011L0 1,639,440
2021/2022 Estriol - 0702010F0 823,969
2021/2022 Progesterone - 0604012S0 795,620
2022/2023 Estradiol - 0604011G0 3,920,916
2022/2023 Estradiol - 0702010G0 1,497,164
2022/2023 Estradiol with progestogen - 0604011L0 2,186,454
2022/2023 Estriol - 0702010F0 1,038,860
2022/2023 Progesterone - 0604012S0 1,630,061
2023/2024 Estradiol - 0604011G0 4,998,153
2023/2024 Estradiol - 0702010G0 1,676,322
2023/2024 Estradiol with progestogen - 0604011L0 2,396,212
2023/2024 Estriol - 0702010F0 1,226,555
2023/2024 Progesterone - 0604012S0 2,329,858
2024/2025
(YTD June 2024)
Estradiol - 0604011G0 1,377,583
2024/2025
(YTD June 2024)
Estradiol - 0702010G0 449,553
2024/2025
(YTD June 2024)
Estradiol with progestogen - 0604011L0 596,787
2024/2025
(YTD June 2024)
Estriol - 0702010F0 344,611
2024/2025
(YTD June 2024)
Progesterone - 0604012S0 664,476

Source: Hormone Replacement Therapy summary tables - annual

In 2023/24 Estradiol (0604011G0) remained the chemical substance with the largest number of items prescribed.

5 million Estradiol (0604011G0) items were prescribed in 2023/24.

Between 2022/23 and 2023/24, Estradiol (0604011G0) was the chemical substance with the largest increase in items prescribed.

There were 5.0 million items Estradiol (0604011G0) items prescribed in 2023/24, 1.08 million more items, or a 27.5% increase, from 3.92 million items in the previous year.

Table 7: Top 10 presentations by prescribed items in 2023/2024

Presentations

Pharmaceutical presentations can come in many forms including tablets, capsules, patches, gels, creams and more. Please see the definition of items and quantity given in section 1.2 to help interpret table 7.

The chemical substance listed in figures 4 and 5 can be made up of more than one of the presentations in table 7. For example, both Vagifem 10 microgram vaginal tablets and Estradiol 10 microgram pessaries have the chemical substance of Estradiol.

Table 7 includes the BNF presentation that appeared on the prescription form. It is possible that products that are different brands, or generic equivalents, of the same product may appear separately in these tables. For example, Oestrogel Pump-Pack 0.06% gel is the branded equivalent of Estradiol 0.06% gel (750 microgram per actuation) and Vagifem 10 microgram vaginal tablets is the branded equivalent of Estradiol 10 microgram pessaries.

Source: Hormone Replacement Therapy summary tables - annual

Utrogestan 100mg capsules had the largest number of items prescribed in 2023/24, with 1.33 million items. This was a 41.7% increase from 935,000 items in 2022/23.

Estimated number of identified patients per 1,000 population by Integrated Care Board (ICB) in 2023/2024

Chart
Figure 6: The number of identified patients prescribed HRT items per 1,000 population varied by ICB
Table
Table 8: The number of identified patients prescribed HRT items per 1,000 population varied by ICB
Financial year ICB name ICB code Patients per 1,000 population
2023/2024 NHS CORNWALL AND THE ISLES OF SCILLY INTEGRATED CARE BOARD QT6 68.2
2023/2024 NHS GLOUCESTERSHIRE INTEGRATED CARE BOARD QR1 67.6
2023/2024 NHS DEVON INTEGRATED CARE BOARD QJK 64.5
2023/2024 NHS SUSSEX INTEGRATED CARE BOARD QNX 64.5
2023/2024 NHS DORSET INTEGRATED CARE BOARD QVV 63.7
2023/2024 NHS HEREFORDSHIRE AND WORCESTERSHIRE INTEGRATED CARE BOARD QGH 63.7
2023/2024 NHS SURREY HEARTLANDS INTEGRATED CARE BOARD QXU 63.0
2023/2024 NHS BATH AND NORTH EAST SOMERSET, SWINDON AND WILTSHIRE INTEGRATED CARE BOARD QOX 60.8
2023/2024 NHS SOMERSET INTEGRATED CARE BOARD QSL 60.7
2023/2024 NHS NORFOLK AND WAVENEY INTEGRATED CARE BOARD QMM 58.8
2023/2024 NHS HAMPSHIRE AND ISLE OF WIGHT INTEGRATED CARE BOARD QRL 57.9
2023/2024 NHS BUCKINGHAMSHIRE, OXFORDSHIRE AND BERKSHIRE WEST INTEGRATED CARE BOARD QU9 56.0
2023/2024 NHS SUFFOLK AND NORTH EAST ESSEX INTEGRATED CARE BOARD QJG 55.9
2023/2024 NHS SHROPSHIRE, TELFORD AND WREKIN INTEGRATED CARE BOARD QOC 53.5
2023/2024 NHS DERBY AND DERBYSHIRE INTEGRATED CARE BOARD QJ2 53.2
2023/2024 NHS BRISTOL, NORTH SOMERSET AND SOUTH GLOUCESTERSHIRE INTEGRATED CARE BOARD QUY 52.8
2023/2024 NHS HUMBER AND NORTH YORKSHIRE INTEGRATED CARE BOARD QOQ 52.8
2023/2024 NHS CHESHIRE AND MERSEYSIDE INTEGRATED CARE BOARD QYG 51.9
2023/2024 NHS HERTFORDSHIRE AND WEST ESSEX INTEGRATED CARE BOARD QM7 50.4
2023/2024 NHS FRIMLEY INTEGRATED CARE BOARD QNQ 49.9
2023/2024 NHS KENT AND MEDWAY INTEGRATED CARE BOARD QKS 48.0
2023/2024 NHS LINCOLNSHIRE INTEGRATED CARE BOARD QJM 47.8
2023/2024 NHS COVENTRY AND WARWICKSHIRE INTEGRATED CARE BOARD QWU 47.5
2023/2024 NHS NOTTINGHAM AND NOTTINGHAMSHIRE INTEGRATED CARE BOARD QT1 47.2
2023/2024 NHS CAMBRIDGESHIRE AND PETERBOROUGH INTEGRATED CARE BOARD QUE 47.0
2023/2024 NHS NORTHAMPTONSHIRE INTEGRATED CARE BOARD QPM 46.2
2023/2024 NHS LANCASHIRE AND SOUTH CUMBRIA INTEGRATED CARE BOARD QE1 46.1
2023/2024 NHS NORTH EAST AND NORTH CUMBRIA INTEGRATED CARE BOARD QHM 45.0
2023/2024 NHS MID AND SOUTH ESSEX INTEGRATED CARE BOARD QH8 44.5
2023/2024 NHS WEST YORKSHIRE INTEGRATED CARE BOARD QWO 43.3
2023/2024 NHS STAFFORDSHIRE AND STOKE-ON-TRENT INTEGRATED CARE BOARD QNC 43.1
2023/2024 NHS SOUTH YORKSHIRE INTEGRATED CARE BOARD QF7 41.0
2023/2024 NHS LEICESTER, LEICESTERSHIRE AND RUTLAND INTEGRATED CARE BOARD QK1 40.4
2023/2024 NHS SOUTH WEST LONDON INTEGRATED CARE BOARD QWE 40.1
2023/2024 NHS GREATER MANCHESTER INTEGRATED CARE BOARD QOP 37.4
2023/2024 NHS BEDFORDSHIRE, LUTON AND MILTON KEYNES INTEGRATED CARE BOARD QHG 37.2
2023/2024 NHS BIRMINGHAM AND SOLIHULL INTEGRATED CARE BOARD QHL 32.9
2023/2024 NHS SOUTH EAST LONDON INTEGRATED CARE BOARD QKK 32.3
2023/2024 NHS NORTH CENTRAL LONDON INTEGRATED CARE BOARD QMJ 31.5
2023/2024 NHS BLACK COUNTRY INTEGRATED CARE BOARD QUA 27.4
2023/2024 NHS NORTH WEST LONDON INTEGRATED CARE BOARD QRV 27.0
2023/2024 NHS NORTH EAST LONDON INTEGRATED CARE BOARD QMF 19.2

Source: Hormone Replacement Therapy summary tables - annual | Office for National Statistics - Mid-2022 ICB Mid-year population estimates

NHS North East London ICB had the lowest estimated number of identified patients who received at least one HRT item per 1,000 residents. It had an estimated 19 patients per 1,000 population in 2023/24.

NHS Cornwall and the Isles of Scilly ICB had the highest estimated number of identified patients who received at least one HRT item per 1,000 residents. It had an estimated 68 patients per 1,000 population in 2023/23.

In England in 2023/24, the estimated number of identified patients who received at least one HRT item per 1,000 population was 46.

Estimated number of identified patients by age band in 2023/2024

Chart
Figure 7: Patients aged 50 to 54 were the largest prescribing group for HRT in 2023/24
Table
Table 9: Patients aged 50 to 54 were the largest prescribing group for HRT in 2023/24
Financial year Age band Identified patients
2023/2024 00-04 277
2023/2024 05-09 183
2023/2024 10-14 776
2023/2024 15-19 5,042
2023/2024 20-24 13,574
2023/2024 25-29 19,746
2023/2024 30-34 26,678
2023/2024 35-39 42,561
2023/2024 40-44 132,780
2023/2024 45-49 386,789
2023/2024 50-54 637,495
2023/2024 55-59 530,599
2023/2024 60-64 294,688
2023/2024 65-69 171,899
2023/2024 70-74 135,496
2023/2024 75-79 118,999
2023/2024 80-84 64,061
2023/2024 85-89 32,823
2023/2024 90+ 13,118
2023/2024 Unknown 16,584

Source: Hormone Replacement Therapy summary tables - annual

In 2023/24 patients aged 50 to 54 were the largest group of identified patients.

640,000 identified patients were aged 50 to 54, almost a quarter of all identified patients in 2023/34.

In 2023/24 patients aged 50 to 54 were the most common group to receive prescribing for HRT, with an estimated 637,000 identified patients. This was 24.1% of all identified patients who received an HRT item in 2023/24. The second most common group was patients aged 55 to 59 with 531,000 patients, 20.1% of all identified patients who received an HRT item in 2023/24.

Estimated number of identified patients by IMD quintile in 2023/2024

Chart
Figure 8: More people were prescribed HRT in less deprived areas in 2023/24
Table
Table 10: More people were prescribed HRT in less deprived areas in 2023/24
Financial year IMD quintile Identified patients
2023/2024 1 - most deprived 324,630
2023/2024 2 434,185
2023/2024 3 557,009
2023/2024 4 636,807
2023/2024 5 - least deprived 739,597

Source: Hormone Replacement Therapy summary tables - annual

740,000 patients prescribed HRT items in the least deprived areas in England in 2023/24.

320,000 patients prescribed HRT items in the most deprived areas in England in 2023/24.

An estimated 740,000 identified patients were prescribed HRT items in the least deprived areas in England in 2023/24. This was more than double the estimated 325,000 identified patients in the most deprived areas. In general more people were prescribed HRT in less deprived areas in 2023/24, and this pattern has been consistent since 2015/16.

The English Indices of Deprivation have been used to provide a measure of patient deprivation. The deprivation quintiles reported are those of the patient’s registered address. More information on this measure can be found in section 4 of this summary.

Proportion of chargeable items by financial year

Prescription charges

In England, a charge applies to NHS prescriptions unless a valid exemption is held. Items dispensed to non exempt patients are counted as chargeable. Certain groups are exempt from paying for their NHS prescriptions, for example those over the age of 60. Some prescribed items are always free, including contraceptives.

If a patient regularly pays prescription charges, a Prescription Prepayment certificate (PPC) could save them money by paying one upfront cost annually or for a 3 month period.

An annual HRT PPC was introduced in April 2023 that covers medicines licensed to treat the menopause in the UK.

Prescriptions covered by either a PPC or HRT PPC are classed as exempt in the data, because the patient does not pay when collecting the medication. PPC has been included in the ‘Other exemptions’ category.

Patients aged under 16 or 60 and over are eligible to claim free prescriptions. Patients do not need to provide proof of age when claiming prescriptions under the age exemption if their date of birth is printed electronically on the prescription. Therefore support with prescription costs, such as exemptions or PPCs, is generally only applicable to patients aged between 16 and 59.

It is not possible to break exempt prescriptions down by category, as this data is not always recorded. More information can be found in section 3 of this summary. You can find more information on HRT PPC data in the NHS Help with Help Costs England publication.

Chart
Figure 9: The proportion of HRT items exempt from prescription charges has increased since 2021/22
Table
Table 11: The proportion of HRT items exempt from prescription charges has increased since 2021/22
Financial year Charge status Total items Proportion of items (%)
2015/2016 Age exempt 1,266,085 40.50
2015/2016 Charged 731,083 23.40
2015/2016 Other exemptions 1,131,824 36.20
2016/2017 Age exempt 1,402,035 40.00
2016/2017 Charged 845,570 24.10
2016/2017 Other exemptions 1,260,230 35.90
2017/2018 Age exempt 1,549,509 38.70
2017/2018 Charged 1,014,830 25.30
2017/2018 Other exemptions 1,442,793 36.00
2018/2019 Age exempt 1,712,981 38.10
2018/2019 Charged 1,167,595 26.00
2018/2019 Other exemptions 1,616,510 35.90
2019/2020 Age exempt 1,948,527 36.80
2019/2020 Charged 1,396,012 26.40
2019/2020 Other exemptions 1,952,592 36.90
2020/2021 Age exempt 1,997,448 36.80
2020/2021 Charged 1,385,334 25.60
2020/2021 Other exemptions 2,037,790 37.60
2021/2022 Age exempt 2,333,717 31.40
2021/2022 Charged 2,138,976 28.70
2021/2022 Other exemptions 2,967,824 39.90
2022/2023 Age exempt 2,984,759 27.30
2022/2023 Charged 3,279,001 30.00
2022/2023 Other exemptions 4,668,848 42.70
2022/2023 Used HRT PPC 665 0.01
2023/2024 Age exempt 3,507,432 26.40
2023/2024 Charged 1,902,773 14.30
2023/2024 Other exemptions 5,944,752 44.70
2023/2024 Used HRT PPC 1,930,184 14.50
2024/2025
(YTD June 2024)
Age exempt 968,156 27.00
2024/2025
(YTD June 2024)
Charged 375,802 10.50
2024/2025
(YTD June 2024)
Other exemptions 1,499,436 41.80
2024/2025
(YTD June 2024)
Used HRT PPC 743,513 20.70

Source: Hormone Replacement Therapy summary tables - annual | Hormone Replacement Therapy tables - exemption category management information

In 2023/24, 85.7% of HRT items were exempt from prescription charges at the point of dispensing, an increase from 70.0% in 2022/23. This trend has continued into the first financial quarter of 2024/25, increasing to 89.5% of HRT items for quarter 1 which covers April to June 2024.

In 2023/24, the proportion of HRT items for which an HRT PPC was used was 14.5%. This was the first financial year where the HRT PPC was available. For the first financial quarter of 2024/25 covering April to June 2024, this increased to 20.7% of HRT items.

Proportion of chargeable items by month April 2023 to June 2024

Chart
Figure 10: The overall proportion of HRT items exempt from prescription charges increased every month since April 2023
Table
Table 12: The proportion of HRT items exempt from prescription charges increased every month since April 2023
Year month Charge status Total items Proportion of items (%)
202304 Age exempt 257,424 26.60
202304 Charged 204,378 21.10
202304 Other exemptions 468,851 48.40
202304 Used HRT PPC 38,746 4.00
202305 Age exempt 276,976 26.80
202305 Charged 197,728 19.10
202305 Other exemptions 490,539 47.40
202305 Used HRT PPC 69,211 6.69
202306 Age exempt 279,126 26.80
202306 Charged 178,289 17.10
202306 Other exemptions 482,121 46.30
202306 Used HRT PPC 100,926 9.70
202307 Age exempt 291,076 25.00
202307 Charged 184,091 15.80
202307 Other exemptions 545,622 46.90
202307 Used HRT PPC 142,088 12.20
202308 Age exempt 296,151 26.40
202308 Charged 162,016 14.50
202308 Other exemptions 511,899 45.70
202308 Used HRT PPC 150,211 13.40
202309 Age exempt 291,487 26.20
202309 Charged 152,941 13.80
202309 Other exemptions 501,414 45.10
202309 Used HRT PPC 165,887 14.90
202310 Age exempt 296,167 26.10
202310 Charged 149,611 13.20
202310 Other exemptions 501,581 44.30
202310 Used HRT PPC 185,895 16.40
202311 Age exempt 304,662 26.60
202311 Charged 144,404 12.60
202311 Other exemptions 496,395 43.40
202311 Used HRT PPC 198,169 17.30
202312 Age exempt 297,871 26.70
202312 Charged 135,705 12.20
202312 Other exemptions 481,115 43.10
202312 Used HRT PPC 201,769 18.10
202401 Age exempt 317,745 26.70
202401 Charged 137,537 11.60
202401 Other exemptions 509,824 42.90
202401 Used HRT PPC 224,123 18.80
202402 Age exempt 298,795 26.80
202402 Charged 128,127 11.50
202402 Other exemptions 472,269 42.30
202402 Used HRT PPC 217,149 19.50
202403 Age exempt 299,952 26.20
202403 Charged 127,946 11.20
202403 Other exemptions 483,122 42.10
202403 Used HRT PPC 236,010 20.60
202404 Age exempt 322,362 27.00
202404 Charged 126,099 10.60
202404 Other exemptions 498,716 41.70
202404 Used HRT PPC 247,698 20.70
202405 Age exempt 333,051 27.10
202405 Charged 128,428 10.50
202405 Other exemptions 513,783 41.80
202405 Used HRT PPC 252,613 20.60
202406 Age exempt 312,743 26.90
202406 Charged 121,275 10.40
202406 Other exemptions 486,937 41.80
202406 Used HRT PPC 243,202 20.90

Source: Hormone Replacement Therapy summary tables - monthly | Hormone Replacement Therapy tables - exemption category management information

The overall proportion of HRT prescribing that is exempt from prescription charges has increased every month from April 2023 to June 2024. In June 2024, 89.6% of HRT prescribing was exempt from prescription charges, compared to 82.9% in June 2023.

Since HRT PPCs were introduced in April 2023, the proportion of HRT prescribing that is exempt from prescription charges at the point of dispensing due to use of an HRT PPC increased in most months. The only decrease was small, from 20.7% in April 2024 to 20.6% in May 2024. In June 2024, 20.9% of HRT prescribing was exempt from prescription charges due to use of an HRT PPC, compared to 9.7% in June 2023.

Between September 2023 and June 2024, a higher proportion of HRT items were exempt from prescription charges due to use of an HRT PPC than were charged.

3. Background

The menopause is a biological stage in a woman’s life that occurs when she stops menstruating and reaches the end of her natural reproductive life. This is not usually abrupt, but a gradual process during which women experience perimenopause before reaching postmenopause. Usually the menopause is defined as having occurred when a woman has not had a period for 12 consecutive months (for women reaching menopause naturally).

As well as a change in their menstrual cycle women may experience a variety of symptoms associated with menopause such as hot flushes and sweats, low mood, vaginal dryness, low sexual desire, and others.

Most women will experience some symptoms. Symptoms can last for months or years, and can change with time. Prolonged lack of the hormone oestrogen affects the bones and cardiovascular system, and postmenopausal women are at increased risk of a number of long-term conditions, such as osteoporosis.

HRT, which replaces the hormones that are at low levels, is the main medicine treatment for menopause and perimenopause symptoms. More information on the menopause is available on the NHS website.

3.1. Included drugs

This publication includes all drugs that have been covered by an HRT PPC. The HRT PPC exempts patients from charges for drugs licensed to treat menopause in the UK. You can find the most up to date list of drugs included in the HRT PPC on the NHSBSA website.

A list of all drugs that are included in this release, including any that are no longer listed due to classification changes or discontinuation can be found in Appendix A.

3.1.1. Female sex hormones and their modulators

Oestrogen-only HRT is usually only recommended for women who have had their womb removed during a hysterectomy. For women with a uterus, oestrogen plus progestogen HRT is recommended. A progestogen item should be prescribed to reduce the risk of cystic hyperplasia of the endometrium, a thickening of the endometrium, and possible transformation to cancer.

HRT comes in several different forms such as tablets and skin patches. The treatment routine for HRT depends on whether the patient is in the early stages of the menopause or has had menopausal symptoms for some time. More information on the types and routines of HRT treatment can be found on the NHS website.

The 2 types of routines are cyclical (or sequential) HRT and continuous combined HRT.

Continuous combined preparations are not suitable for use in the perimenopause or within 12 months of the last menstrual period. Women who use such preparations may bleed irregularly in the early stages of treatment.

You can find out more information on sex hormones on the NICE website.

3.1.2. Preparations for vaginal and vulval changes

Preparations for vaginal and vulval changes are used to treat the symptoms of vaginal atrophy related to oestrogen deficiencies related to the menopause.

There are non-hormonal vaginal moisturisers available. Menopausal women with vaginal dryness can use vaginal moisturisers and lubricants alone or in addition to vaginal oestrogen.

You can find out more information on vaginal and vulval conditions on the NICE website.

3.1.3. Anabolic steroids

Prasterone

Prasterone is biochemically and biologically identical to endogenous dehydroepiandrosterone (DHEA), and is converted to oestrogens and androgens. It is used to treat vulvar and vaginal atrophy in postmenopausal women.

You can find out more information on prasterone on the NICE website.

3.1.4. Progesterone only contraception

Intrauterine system (IUS), or Mirena coil

For patients who have a womb and are taking or using oestrogen tablets, patches, gel or spray, the Mirena coil, an intrauterine system (IUS), may be a suitable way to deliver the progestogen they need.

The Mirena coil is inserted into the womb and it gradually releases a form of progestogen (levonorgestrel) into the body.

You can find out more information on levonorgestrel on the NICE website.

3.2. Gina 10 microgram vaginal tablets

Pharmacists in the UK can now dispense the HRT drug Gina 10 microgram vaginal tablets without a prescription.

Gina 10 microgram vaginal tablets are a locally acting oestrogen HRT and the only treatment available without a prescription. It has been clinically proven to target and treat the cause of vaginal atrophy and its associated symptoms after the menopause.

Gina 10 microgram vaginal tablets are a proprietary equivalent of Estradiol 10 microgram pessaries. The NHSBSA does not collect information about medicines that are sold over the counter. These statistics therefore may not be representative of the whole population taking HRT.

3.3. Exemption categories

Exemption category data for most exemptions is not included in these statistics due to a number of known data quality issues. Exemption category data is released alongside this publication to complement the HRT statistics, but is management information only. Users should exercise caution when using the exemption category data provided alongside these statistics.

It is possible for a patient to have multiple valid exemptions, including holding multiple exemption certificates. However, within NHS prescription data processed by the NHSBSA, only a single exemption category is identified against any individual form/item.

In a large number of cases the NHSBSA does not record a specific exemption category. A common reason for our records stating ‘No Declaration/Declaration Not Specific’ is the increasing use of the Real Time Exemption Checking service (RTEC). This service confirms to the dispenser that a person was exempt from the charge, but no record of the reason found by RTEC is passed on to NHSBSA prescription processing systems.

For paper prescriptions, the mark(s) on the rear of the form intended to indicate one, or more, exemption reason(s) is not clear and can be misinterpreted by the NHSBSA scanners.

NHSBSA performs no validation or verification of which exemption category has been marked or recorded during scanning.

The reported exemption category will represent the data as submitted by dispensing accounts and processed by NHSBSA to inform reimbursement.

3.3.1 Charge status

The charge status categories included in this narrative are:

  • age exempt
  • used HRT PPC
  • other exemptions
  • charged

NHS prescriptions are free to all patients aged under 16 or 60 or over. Although these may be claimed as separate exemption categories, they have been combined for reporting purposes within this article. Patients aged under 16 or over 59 do not need to provide proof of age when claiming prescriptions under the age exemption if their date of birth is printed electronically on the prescription. Students aged 16-18 in full time education are also eligible for free prescriptions but must provide proof, and have been included in the ‘other exemptions’ charge status category instead.

An HRT PPC can be purchased by patients to cover all their NHS prescriptions for applicable medicines licensed to treat menopause in the UK. The HRT PPC was introduced in April 2023. Certificates are valid for a period of 12-months and are purchased via a single up-front payment. Although this category is separate to ‘Charge Paid’, it should be noted that patients with these certificates are not receiving NHS prescribing free of charge. Instead, patients pay for a certificate to help with health costs rather than paying for prescriptions at the point of dispensing.

All other prescription charge exemptions, once age-related exemptions and HRT PPC have been removed, have been combined as a single other exemptions reporting group. This group includes prescriptions claimed using a regular PPC, where the patient buys a 3 or 12-month certificate to cover all their NHS prescriptions.

Patients without any valid payment exemption will pay a prescription charge for each prescription item they receive. This prescription charge is paid at the point of dispensing. The charged category covers items which were paid for at the point of dispensing and will not include items for patients who have purchased a PPC or HRT PPC.

4. About these statistics

These statistics are an official statistics in development publication by the NHSBSA. To learn more about how this publication compares to our other publications, you can view the Official Statistics guidance table on our statistical collections page.

Further information on the methodology used in this publication and further background information is available in our Background Information and Methodology supporting document.

4.1. Changes to these statistics

This release includes all drugs that are covered by the HRT PPC, introduced in April 2023. The HRT PPC provides exemption from prescription charges for drugs licensed to treat menopause in the UK. The list of drugs is subject to change and the following changes have happened during the time period covered in the data for this release:

  • Tibolone 2.5mg tablets (Livial) and Prasterone 6.5mg pessaries (Intrarosa) were added to the list from June 2023
  • Gepretix – Progesterone micronised 100mg capsules were added to the list from November 2023

As a result of these changes, some data for historical years may have changed from the previous release in this publication series. You should always use the latest data available.

4.2. Patient counts

The patient counts shown in these statistics should only be analysed at the level at which they are presented. Adding together any patient counts is likely to result in an overestimate of the number of patients. A patient will be included, or counted, in each category or time period in which they received relevant prescriptions. For example, if a patient received a prescription item for HRT in January 2024, and another in February 2024, then adding together those totals would count that patient twice. For the same reason, data on patient counts for different BNF sections should not be added together.

4.3. Patient age

The age of patients used in these statistics is derived from data provided by the NHS Personal Demographics Service (PDS) for NHS numbers that have been successfully verified by them. A patient’s age, used to assign them to an age group, has been calculated on 30 September for the given financial year. It is possible that a patient’s PDS information may change over the course of the year. In these cases patients may be subject to multiple counting in these analyses.

4.4. Averages

Where this document refers to ‘average’, this is the mean unless otherwise stated. This is calculated by adding the number of items/patients/months together and dividing this by the number of items/patients/months.

4.5. Index of deprivation

The English Indices of Deprivation 2019 have been used to provide a measure of patient deprivation. The English Indices of Deprivation are an official national measure of deprivation that follows an established methodological framework to capture a wide range of individuals’ living conditions.

The reported Index of Multiple Deprivation (IMD) quintile, where 1 is the most deprived and 5 the least deprived, is derived from the lower-layer super output areas (LSOA) of the registered address of the patient who received the medication. There are a number of items each year that we have reported as having an unknown IMD quintile. These are items that have been attributed to an patient who exclusively received their prescriptions via paper prescribing and not via the Electronic Prescription Service (EPS). LSOA is only captured for prescriptions via EPS. For those patients who received both paper prescribing and EPS we have imputed their LSOA from the latest available data. The use of EPS increased considerably during 2020/21. Therefore historical data has much higher rates of patients with a LSOA which has been reported as ‘Unknown’.

IMD quintiles are calculated by ranking census LSOA from most deprived to least deprived and dividing them into 5 equal groups. These range from the most deprived 20% (quintile 1) of small areas nationally to the least deprived 20% (quintile 5) of small areas nationally.

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